Ku80 is required for immunoglobulin isotype switching.

@article{Casellas1998Ku80IR,
  title={Ku80 is required for immunoglobulin isotype switching.},
  author={Rafael Casellas and Andr{\'e} Nussenzweig and Robert Wuerffel and Roberta Pelanda and Amy Reichlin and Heikyung Suh and Xiaoli Qin and Eva Besmer and Annegien Kenter and K. Rajewsky and Michel C. Nussenzweig},
  journal={The EMBO journal},
  year={1998},
  volume={17 8},
  pages={2404-11}
}
Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In contrast to V(D)J recombination, which is mediated by RAG1, RAG2 and DNA double-stranded break (DSB) repair proteins, little is known about the mechanism of switching. We have investigated the role of DNA DSB repair in switch recombination in mice that are unable to repair DSBs due to a deficiency in Ku80 (Ku80(-/-)). B-cell development is arrested at the pro-B cell stage… CONTINUE READING

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Chromosomal double-strand break repair in Ku80-deficient cells.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 4 Excerpts
Highly Influenced

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

Proceedings of the National Academy of Sciences of the United States of America • 1991
View 5 Excerpts
Highly Influenced

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