Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.

Abstract

Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80(-/-) mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis… (More)
DOI: 10.1158/0008-5472.CAN-08-2085

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@article{Holcomb2008Ku80DS, title={Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.}, author={Valerie B. Holcomb and Francis Rodier and YongJun Choi and Rita A. Busuttil and Hannes Vogel and Jan Vijg and Judith Campisi and Paul Hasty}, journal={Cancer research}, year={2008}, volume={68 22}, pages={9497-502} }