Ku Must Load Directly onto the Chromosome End in Order to Mediate Its Telomeric Functions

Abstract

The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this mechanism could be challenged by factors known to bind directly to the chromosome terminus. This has led to… (More)
DOI: 10.1371/journal.pgen.1002233

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