Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.

@article{Emerson2018KuDE,
  title={Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.},
  author={Charlene H. Emerson and Christopher R. Lopez and Albert Ribes-Zamora and Erica J Polleys and Christopher L. Williams and Lythou Yeo and Jacques Eric Zaneveld and Rui Chen and Alison A Bertuch},
  journal={Genetics},
  year={2018},
  volume={209 1},
  pages={
          115-128
        }
}
The Ku heterodimer acts centrally in nonhomologous end-joining (NHEJ) of DNA double-strand breaks (DSB). Saccharomyces cerevisiae Ku, like mammalian Ku, binds and recruits NHEJ factors to DSB ends. Consequently, NHEJ is virtually absent in yeast Ku null (yku70∆ or yku80∆) strains. Previously, we unexpectedly observed imprecise NHEJ proficiency in a yeast Ku… CONTINUE READING