Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.

@article{Cao2009KruppellikeFK,
  title={Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.},
  author={Zhuoxiao Cao and A K M Khyrul Wara and Basak Icli and Xuehao Sun and Ren{\'e} R S Packard and Fehim Esen and Christopher J Stapleton and Malayannan Subramaniam and Karsten Kretschmer and Irina Apostolou and Harald von Boehmer and G{\"o}ran K. Hansson and Thomas C. Spelsberg and Peter Libby and Mark W. Feinberg},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 37},
  pages={24914-24}
}
CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely understood. Herein, we provide evidence that Kruppel-like factor 10 (KLF10/TIEG1) constitutes an important regulator of T regulatory cell suppressor function and CD4(+)CD25(-) T cell activation through distinct mechanisms involving transforming growth factor (TGF)-beta1 and Foxp3… CONTINUE READING
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Targets TGF- 1 in CD4 CD25 T Cells and T Regs 24924 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M. W. Feinberg, K. Shimizu, +9 authors M. K. Jain
  • July 14,
  • 2004
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