Kruppel-like factor-9 (KLF9) inhibits glioblastoma stemness through global transcription repression and integrin α6 inhibition.

@article{Ying2014KruppellikeF,
  title={Kruppel-like factor-9 (KLF9) inhibits glioblastoma stemness through global transcription repression and integrin α6 inhibition.},
  author={Mingyao Ying and Jessica I. Tilghman and Yingying Wei and Hugo Guerrero-Cazares and Alfredo Quinones-Hinojosa and Hongkai Ji and John Laterra},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 47},
  pages={
          32742-56
        }
}
It is increasingly important to understand the molecular basis for the plasticity of neoplastic cells and their capacity to transition between differentiated and stemlike phenotypes. Kruppel-like factor-9 (KLF9), a member of the large KLF transcription factor family, has emerged as a regulator of oncogenesis, cell differentiation, and neural development; however, the molecular basis for the diverse contextual functions of KLF9 remains unclear. This study focused on the functions of KLF9 in… CONTINUE READING
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