Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.

@article{Shinoda2008KruppellikeF5,
  title={Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.},
  author={Yusuke Shinoda and Naoshi Ogata and Akiro Higashikawa and Ichiro Manabe and T. Shindo and Takashi Yamada and Fumitaka Kugimiya and Toshiyuki Ikeda and Naohiro Kawamura and Yosuke Kawasaki and Kensuke Tsushima and Norifumi Takeda and Ryozo Nagai and Kazuto Hoshi and Kozo Nakamura and Ung-il Chung and Hiroshi Kawaguchi},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 36},
  pages={
          24682-9
        }
}
Although degradation of cartilage matrix has been suggested to be a rate-limiting step for endochondral ossification during skeletal development, little is known about the transcriptional regulation. This study investigated the involvement of KLF5 (Krüppel-like factor 5), an Sp/KLF family member, in the skeletal development. KLF5 was expressed in chondrocytes and osteoblasts but not in osteoclasts. The heterozygous deficient (KLF5+/-) mice exhibited skeletal growth retardation in the perinatal… CONTINUE READING
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