Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen.

@article{Park2012KruppellikeF4,
  title={Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen.},
  author={Chun Shik Park and Ping-Hsien Lee and Takeshi Yamada and Audrea M. Burns and Ye Shen and Monica Puppi and H. Daniel Lacorazza},
  journal={Journal of leukocyte biology},
  year={2012},
  volume={91 5},
  pages={739-50}
}
The development and survival of NK cells rely on a complex, spatiotemporal gene expression pattern regulated by specific transcription factors in NK cells and tissue-specific microenvironments supported by hematopoietic cells. Here, we show that somatic deletion of the KLF4 gene, using inducible and lineage-specific cre-transgenic mice, leads to a significant reduction of NK cells (NK1.1(+) TCR-β(-)) in the blood and spleen but not in the BM, liver, or LNs. Functional and immunophenotypic… CONTINUE READING

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