Kruppel-like factor 2 regulates thymocyte and T-cell migration

  title={Kruppel-like factor 2 regulates thymocyte and T-cell migration},
  author={Corey M. Carlson and Bart T. Endrizzi and Jinghai Wu and Xiaojie Ding and Michael A. Weinreich and Elizabeth Rose Walsh and Maqsood A. Wani and Jerry B. Lingrel and Kristin A Hogquist and Stephen C Jameson},
Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking. KLF2-deficient (Klf2-/-) thymocytes show impaired expression of several receptors required for thymocyte emigration and… CONTINUE READING
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