Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass.

@article{Gabet2010Krox20EGR2DA,
  title={Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass.},
  author={Yankel Gabet and Sanjeev K. Baniwal and Nathalie Leclerc and Yunfan Shi and Alice E Kohn-Gabet and Jon P. Cogan and Alexis Dixon and Marilyn Bachar and Li-Xin Guo and Jack Edward Turman and Baruch Frenkel},
  journal={Blood},
  year={2010},
  volume={116 19},
  pages={
          3964-71
        }
}
Krox20/EGR2, one of the 4 early growth response genes, is a highly conserved transcription factor implicated in hindbrain development, peripheral nerve myelination, tumor suppression, and monocyte/macrophage cell fate determination. Here, we established a novel role for Krox20 in postnatal skeletal metabolism. Microcomputed tomographic analysis of 4- and 8-week-old mice revealed a low bone mass phenotype (LBM) in both the distal femur and the vertebra of Krox20(+/-) mice. This was attributable… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Erythropoietin directly stimulates osteoclast precursors and induces bone loss.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2015
VIEW 2 EXCERPTS
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES