Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain

  title={Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain},
  author={Tania Seitanidou and Sylvie Schneider-Maunoury and Carole Desmarquet and David G Wilkinson and Patrick Charnay},
  journal={Mechanisms of Development},
The morphogenesis of the vertebrate hindbrain involves a transient segmentation process leading to the formation of reiterated organisation units called rhombomeres (r). A number of regulatory genes expressed with a rhombomere-specific pattern have been identified, including the gene encoding the transcription factor Krox-20, which is restricted to r3 and r5. We have previously demonstrated that in r3 and r5 Krox-20 directly controls the transcription of Hoxa-2 and Hoxb-2. In the present study… CONTINUE READING


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