Krox-20 controls myelination in the peripheral nervous system

  title={Krox-20 controls myelination in the peripheral nervous system},
  author={Piotr Topilko and Sylvie Schneider-Maunoury and Giovanni Levi and Anne Baron-Van Evercooren and Amina Ben Younes Chennoufi and Tania Seitanidou and Charles Babinet and Patrick Charnay},
THE molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcription factor2,3, by in-frame insertion of the Escherichia coli lacZ gene, and have shown that hindbrain segmentation is affected in Krox-20−/− embryos4. We demonstrate here that Krox… CONTINUE READING
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