Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth.

@article{Cao1997Kringle5O,
  title={Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth.},
  author={Yihai Cao and Ang Chen and Steven S. An and R W Ji and David Davidson and Miguel Llin{\'a}s},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 36},
  pages={22924-8}
}
Angiostatin is a potent angiogenesis inhibitor which has been identified as an internal fragment of plasminogen that includes its first four kringle modules. We have recently demonstrated that the anti-endothelial cell proliferative activity of angiostatin is also displayed by the first three kringle structures of plasminogen and marginally so by kringle 4 (Cao, Y., Ji, R.-W., Davidson, D., Schaller, J., Marti, D., Sohndel, S., McCance, S. G., O'Reilly, M. S. , Llinás, M., and Folkman, J. (1996… CONTINUE READING

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