Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.

@article{Lu1999Kringle5C,
  title={Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.},
  author={Hope Lu and Mohan Dhanabal and R Volk and Matthew J. F. Waterman and Ramani Ramchandran and Bertrand Knebelmann and Michael A Segal and Vikas P Sukhatme},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={258 3},
  pages={668-73}
}
Angiostatin which contains the first four kringle domains of plasminogen has been documented to be a potent inhibitor of angiogenesis. More recently, another kringle structure within plasminogen but outside angiostatin, known as kringle 5 (K5), was found to inhibit endothelial cell proliferation and migration. Here, we report the cloning and expression of mouse kringle 5 (rK5) in a bacterial expression system. The protein was purified to homogeneity using a Ni-NTA column. rK5 inhibited both… CONTINUE READING

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