Krebs and his trinity of cycles
@article{Kornberg2000KrebsAH, title={Krebs and his trinity of cycles}, author={Hans Leo Kornberg}, journal={Nature Reviews Molecular Cell Biology}, year={2000}, volume={1}, pages={225-228} }
Everyone who has ever taken biology at school has heard of the Krebs cycle, but few realize that Hans Krebs also discovered two other cycles. It is appropriate, at the centenary of his birth, to consider the circumstances and experiments that led Krebs to establish these metabolic pathways.
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References
SHOWING 1-10 OF 19 REFERENCES
The path of carbon in photosynthesis.
- ChemistryScience
- 1962
Most, if not all, of the reactions of carbon reduction in photosynthesis are known to occur, although at a diminished rate, in the dark long after the immediate reducing and energy-carrying agents formed from the photochemical reaction have decayed.