Kratom Withdrawal: A Systematic Review with Case Series

@article{Stanciu2019KratomWA,
  title={Kratom Withdrawal: A Systematic Review with Case Series},
  author={Cornel N Stanciu and Samantha A. Gnanasegaram and Saeed Ahmed and Thomas M Penders},
  journal={Journal of Psychoactive Drugs},
  year={2019},
  volume={51},
  pages={12 - 18}
}
ABSTRACT Recent years have seen a widespread increase in kratom use, not just for the purpose of easing opioid withdrawal, but also for management of emotional and mental health concerns by individuals without histories of opioid use. Chronic use can lead to dependence, tolerance, and withdrawal on cessation, and clinicians are seeing an increasing number of presentations involving the latter. Although there is literature discussing the use of kratom to assist in opioid withdrawal, this article… 
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References

SHOWING 1-10 OF 25 REFERENCES
A Case Report of Kratom Addiction and Withdrawal.
  • David Galbis-Reig
  • Medicine
    WMJ : official publication of the State Medical Society of Wisconsin
  • 2016
TLDR
Physicians in the United States should be aware of the growing availability and abuse of kratom and the herb's potential adverse health effects, with particular attention to kratom's toxicity, addictive potential, and associated withdrawal syndrome.
Self-treatment of opioid withdrawal with a dietary supplement, Kratom.
TLDR
This study demonstrates the rapidity with which information on psychoactive substances disseminates through online communities and suggests that online surveillance may be important to the generation of effective opioid analgesic abuse prevention strategies.
Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth).
TLDR
The predominant alkaloid of kratom, mitragynine, binds mu- and kappa-opioid receptors, but has additional receptor affinities that might augment its effectiveness at mitigating opioid withdrawal.
A Case Report of Inpatient Detoxification after Kratom (Mitragyna speciosa) Dependence
TLDR
These observations support the idea that kratom dependence syndrome is due to short-acting opioid receptor agonist activity, and suggest that dihydrocodeine and lofexidine are effective in supporting detoxification.
Patterns of Kratom use and health impact in the US-Results from an online survey.
Kratom Abuse in Ramathibodi Poison Center, Thailand: A Five-Year Experience
TLDR
A retrospective review of Kratom exposure cases from the RPC toxic surveillance system found most cases in both groups had good prognostic outcome, and there was a baby with withdrawal symptoms who was delivered from a chronic Kratom-abusing mother, suggesting possible exposure via the transplacental route.
Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia
TLDR
It is suggested that chronic kratom administration does not significantly impair social functioning of users in a natural context in Malaysia, despite being dependent on kratom for prolonged periods of time.
Is Kratom the New 'Legal High' on the Block?: The Case of an Emerging Opioid Receptor Agonist with Substance Abuse Potential.
TLDR
The goal of this article is to introduce kratom to pain specialists and to spur a conversation on how pain physicians may take the lead to help curb the opioid abuse and overdose epidemic.
Factor Analytical Investigation of Krathom (Mitragyna speciosa Korth.) Withdrawal Syndrome in Thailand
TLDR
Symptoms and signs of krathom withdrawal similar to those of the withdrawal syndrome of opioid substances appear to be present in regular k rathom users and their intensity is predicted by duration ofkrathom use, frequency, and daily amount of kRathom use.
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2
3
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