Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.

  title={Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.},
  author={Michael R. O'Dell and Jing Li Huang and Christa Lynn Whitney-Miller and Vikram Deshpande and Paul G. Rothberg and Valerie Grose and Randall M. Rossi and Andrew X. Zhu and Hartmut Land and Nabeel Bardeesy and Aram F. Hezel},
  journal={Cancer research},
  volume={72 6},
Intrahepatic cholangiocarcinoma (IHCC) is a primary cancer of the liver with an increasing incidence and poor prognosis. Preclinical studies of the etiology and treatment of this disease are hampered by the relatively small number of available IHCC cell lines or genetically faithful animal models. Here we report the development of a genetically engineered mouse model of IHCC that incorporates two of the most common mutations in human IHCC, activating mutations of Kras (Kras(G12D)) and deletion… CONTINUE READING


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Macconaill LE, LauwersGY, et al.Mutational profiling revealsPIK3CAmutations in gallbladder carcinoma

  • V Deshpande, A Nduaguba, SM Zimmerman, SM Kehoe
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