Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.

@article{Nandan2008KrppellikeF5,
  title={Kr{\"u}ppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.},
  author={Mandayam O. Nandan and Beth B. McConnell and Amr M. Ghaleb and Agnieszka B. Bialkowska and Hongmiao Sheng and Jinyi Shao and Brian A. Babbin and Sylvie Robine and Vincent W. Yang},
  journal={Gastroenterology},
  year={2008},
  volume={134 1},
  pages={120-30}
}
BACKGROUND & AIMS Krüppel-like factor 5 (KLF5) is a zinc finger-transcription factor that regulates cell proliferation. Oncogenic KRAS mutations are commonly found in colorectal cancers. We aimed to determine whether KLF5 mediates KRAS functions during intestinal tumorigenesis. METHODS The effects of KLF5 on proliferation and transformation were examined in IEC-6 intestinal epithelial cells stably transfected with inducible KRAS(V12G). KLF5 expression was examined in intestinal tumors derived… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Similar Papers

Loading similar papers…