Krüppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells

@article{Chanchevalap2006KrppellikeF5,
  title={Kr{\"u}ppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells},
  author={Sengthong Chanchevalap and Mandayam O. Nandan and Beth B. McConnell and Laetitia Charrier and Didier Merlin and Jonathan P. Katz and Vincent W. Yang},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={1216 - 1223}
}
Lipopolysaccharide (LPS) is a bacterially-derived endotoxin that elicits a strong proinflammatory response in intestinal epithelial cells. It is well established that LPS activates this response through NF-kappaB. In addition, LPS signals through the mitogen-activated protein kinase (MAPK) pathway. We previously demonstrated that the Krüppel-like factor 5 [KLF5; also known as intestine-enriched Krüppel-like factor (IKLF)] is activated by the MAPK. In the current study, we examined whether KLF5… CONTINUE READING

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