Krüppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5.

@article{Ma2014KrppellikeF4,
  title={Kr{\"u}ppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5.},
  author={Jun Ma and Ping Wang and Yunhui Liu and Lini Zhao and Zhen Li and Yi-xue Xue},
  journal={Journal of cellular physiology},
  year={2014},
  volume={229 7},
  pages={
          916-26
        }
}
Blood-tumor barrier (BTB) constitutes an efficient organization of tight junctions which significantly reduce permeability for chemotherapy drugs. Krüppel-like factor 4 (KLF4), a member of the Krüppel-like family, has been documented in endothelial cells and may serve as an essential regulator of endothelial barrier function. However, our knowledge about the expression and function of KLF4 in the endothelial cells of BTB still remains unclear. In this study, we sought to investigate the role of… CONTINUE READING

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