Krüppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis.

@article{Heo2015KrppellikeF1,
  title={Kr{\"u}ppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis.},
  author={Seung-Ho Heo and Eui-Suk Jeong and Kyoung-Sun Lee and Jin-Hee Seo and Woon-kyu Lee and Yang-Kyu Choi},
  journal={Oncology reports},
  year={2015},
  volume={33 4},
  pages={2037-44}
}
Liver cancer is the third most common cancer, and the incidence as well as the mortality rate of liver cancer are on the increase. There are many signaling pathways that are involved in hepatic tumorigenesis. One of these pathways, the transforming growth factor-β (TGF-β)/Smad pathway with KLF10, has been reported to suppress cellular proliferation in most cases. However, the actual functions of KLF10 in various pathophysiological conditions are still fragmentary and unclear. In the present… CONTINUE READING