Krüppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs

@inproceedings{Liu2010KrppellikeF,
  title={Kr{\"u}ppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs},
  author={Yu Liu and Jin-kun Wen and Li-hua Dong and Bin Zheng and Mei Han},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
AbstractAim:To elucidate how krüppel-like factor (KLF5) activates cyclin D1 expression in Ang II-induced vascular smooth muscle cells (VSMC) proliferation.Methods:An adenoviral vector containing the full-length cDNA of KLF5 and a recombinant plasmid expressing c-Jun were constructed. MTT assay and flow cytometric analysis were used to determine the effect of Ang II on cell growth. The luciferase assay and chromatin immunoprecipitation were used to detect the relationship between KLF5 and c-Jun… CONTINUE READING
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