Krüppel-Like Factor 8 Is a New Wnt/Beta-Catenin Signaling Target Gene and Regulator in Hepatocellular Carcinoma

@inproceedings{Yang2012KrppelLikeF8,
  title={Kr{\"u}ppel-Like Factor 8 Is a New Wnt/Beta-Catenin Signaling Target Gene and Regulator in Hepatocellular Carcinoma},
  author={Tian Rui Yang and Sheng-Yun Cai and Jin Zhang and Jun-hua Lu and Chuan Lung Lin and Jian Zhai and Meng-chao Wu and Feng Shen},
  booktitle={PloS one},
  year={2012}
}
Krüppel-like factor 8 (KLF8) plays important role in cell cycle and oncogenic transformation. Here we report the mechanisms by which KLF8 crosstalks with Wnt/β-catenin signaling pathway and regulates hepatocellular carcinoma (HCC) cells proliferation. We show that overexpression of KLF8 and nucleus accumulation of β-catenin in the human HCC samples are positively correlated. More importantly, KLF8 protein levels plus nucleus accumulation of β-catenin levels were significantly elevated in high… CONTINUE READING

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