Koschei the immortal and anti-aging drugs

  title={Koschei the immortal and anti-aging drugs},
  author={Mikhail V. Blagosklonny},
  booktitle={Cell Death and Disease},
In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei’s anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin… CONTINUE READING