Korean red ginseng extract does not cause embryo-fetal death or abnormalities in mice.

  title={Korean red ginseng extract does not cause embryo-fetal death or abnormalities in mice.},
  author={Sunhee Shin and Ja Young Jang and DongSun Park and Jung-min Yon and In-Jeoung Baek and Bang Yeon Hwang and Sang-Yoon Nam and Young Won Yun and Kyoung In Kim and Seong Soo Joo and Yun-Bae Kim},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  volume={89 1},
BACKGROUND Ginseng has been used for a long time and is well tolerated in humans. However, recent studies have shown that ginsenosides Rb1, Rg1, and Re exert embryotoxicity in in vitro culture systems. We investigated the effects of Korean red ginseng extract (KRGE) on embryonic implantation and fetal development in mice. METHODS Mice were orally administered KRGE (20, 200, or 2,000 mg/kg/day) from 2 weeks before mating to gestational day (GD) 18, and implantation rate, fetal mortality, body… CONTINUE READING


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