Koch’s postulates and infectious proteins

@article{Walker2006KochsPA,
  title={Koch’s postulates and infectious proteins},
  author={Lary C. Walker and Harry Levine and Mathias Jucker},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={1-4}
}
Koch’s postulates were formulated in the late nineteenth century as guidelines for establishing that microbes cause specific diseases. Because the rules were developed for living agents—particularly bacteria—their applicability to inanimate pathogens such as viruses and infectious proteins has been problematic. The unorthodox mechanism by which prion diseases are transmitted, involving specific physicochemical characteristics of the protein as well as susceptibility traits of the host, has made… 
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References

SHOWING 1-10 OF 49 REFERENCES
Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later
  • S. Falkow
  • Biology, Medicine
    Nature Reviews Microbiology
  • 2004
TLDR
These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease.
Emerging principles of conformation-based prion inheritance.
TLDR
The prion hypothesis has been extended with the finding that several non-Mendelian traits in fungi are due to heritable changes in protein conformation, which may in some cases be beneficial.
Causation and Disease: The Henle-Koch Postulates Revisited 1
  • A. Evans
  • Biology, Medicine
    The Yale journal of biology and medicine
  • 1976
TLDR
The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments, and a set of guidelines for both acute infectious and chronic diseases is presented.
Infectivity of amyloid diseases.
TLDR
Amyloid-related therapeutic approaches should not be based on administration of amyloidogenic peptides in conjunction with an inflammatory stimulus, such as in a recently halted clinical trial for Alzheimer's disease.
Introduction to the transmissible spongiform encephalopathies or prion diseases.
  • B. Chesebro
  • Biology, Medicine
    British medical bulletin
  • 2003
TLDR
Understanding of the structure of the disease-associated protease-resistant PrP should help elucidate the mechanism of PrP conversion from the normal to the abnormal form and open up new approaches to both diagnosis and therapy.
Robert Koch - A Life in Medicine and Bacteriology
TLDR
Koch's postulates, a series of guidelines for the experimental study of infectious disease, permitted Koch and his students to identify many of the causes of the most important infectious diseases of humans and animals.
Inducible proteopathies
TLDR
The mechanistic similarities among these diseases provide unprecedented opportunities for elucidating the induction of protein misfolding and assembly in vivo, and for developing an integrated therapeutic approach to degenerative proteopathies.
Pathogenesis of prion diseases
TLDR
Although important roles for microglial neurotoxicity, oxidative stress, and complement activation have been identified, the authors are far from complete understanding, and therapeutic applications in prion diseases still need to be developed.
In Vitro Generation of Infectious Scrapie Prions
TLDR
It is shown that PrPC --> PrPres conversion can be mimicked in vitro by cyclic amplification of protein misfolding, resulting in indefinite amplification of PrPres.
Mammalian Prion Biology One Century of Evolving Concepts
TLDR
The two decades since Stanley Prusiner's formulation of the protein-only hypothesis have witnessed spectacular advances, and yet some of the most basic questions in prion science have remained unanswered.
...
1
2
3
4
5
...