Knowledge of the adenomatous polyposis coli gene and its clinical application.

@article{Petersen1994KnowledgeOT,
  title={Knowledge of the adenomatous polyposis coli gene and its clinical application.},
  author={G. M. van Petersen},
  journal={Annals of medicine},
  year={1994},
  volume={26 3},
  pages={205-8}
}
Familial adenomatous polyposis (FAP) is one of the most clearly defined and well understood of the inherited colorectal cancer syndromes. It is an autosomal dominant condition with high (> 90%) penetrance. Clinically, it is characterized by multiple (> 100) adenomatous polyps in the colon and rectum; variant features in addition to the colonic polyps may include polyps in the upper gastrointestinal tract and other extracolonic manifestations. Since the risk of colorectal cancer in untreated FAP… CONTINUE READING
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