Knowledge guided analysis of microarray data

  title={Knowledge guided analysis of microarray data},
  author={Zhuo Fang and Jiong Yang and Yixue Li and Qing-ming Luo and Lei Liu},
  journal={Journal of biomedical informatics},
  volume={39 4},
To microarray expression data analysis, it is well accepted that biological knowledge-guided clustering techniques show more advantages than pure mathematical techniques. In this paper, Gene Ontology is introduced to guide the clustering process, and thus a new algorithm capturing both expression pattern similarities and biological function similarities is developed. Our algorithm was validated on two well-known public data sets and the results were compared with some previous works. It is… CONTINUE READING


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