Knowledge gaps about rabies transmission from vampire bats to humans

@article{BrockFenton2020KnowledgeGA,
  title={Knowledge gaps about rabies transmission from vampire bats to humans},
  author={M. Brock Fenton and Daniel G. Streicker and Paul A. Racey and Merlin D. Tuttle and Rodrigo A. Medell{\'i}n and Marc J. A. Daley and Sergio Recuenco and Kevin M. Bakker},
  journal={Nature Ecology \& Evolution},
  year={2020},
  volume={4},
  pages={517-518}
}
1Department of Biology, University of Western Ontario, London, Ontario, Canada. 2MRC–University of Glasgow Centre for Virus Research, Glasgow, UK. 3Institute of Biodiversity, Animal Health and Comparative Medicine & College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. 4Centre for Ecology and Conservation, University of Exeter, Penryn, UK. 5Merlin Tuttle’s Bat Conservation, Austin, TX, USA. 6Institute of Ecology, UNAM, Mexico City, Mexico. 7University of Western… 

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References

SHOWING 1-10 OF 20 REFERENCES

Vampire Bats and Rabies: Toward an Ecological Solution to a Public Health Problem

TLDR
This complex system of vampire bats in the greater Amazon Basin and the remote and impoverished nature of communities affected by these outbreaks create challenges beyond those faced in previous rabies control efforts and require new strategies to address this public health menace through ecosystemlevel intervention.

Spatial expansions and travelling waves of rabies in vampire bats

TLDR
It is demonstrated that viral expansions into historically uninfected zones have doubled the recent burden of vampire bat-transmitted rabies, revealing VBR as an emerging rather than an enzootic disease and creating opportunities to test novel interventions to manage viruses in bat reservoirs.

Potential force of infection of human rabies transmitted by vampire bats in the Amazonian region of Brazil.

TLDR
The aim of the present work was to estimate the potential force of infection of human rabies transmitted by the common vampire bat if the rabies virus were to be introduced to a colony of bats close to a village with a high rate of human bites.

Quantifying the burden of vampire bat rabies in Peruvian livestock

TLDR
The long-suspected cost of V BR to small-scale farmers is confirmed and it is shown that vaccinating livestock is a cost-effective solution to mitigate the burden of VBR, highlighting that ignoring geographic variation in access to health resources can bias estimates of disease burden and risk.

BAT-BORNE RABIES IN LATIN AMERICA

TLDR
According to diet type, insectivorous bats had the most species known as rabies reservoirs, while in proportion hematophagous bats were the most important.

Evidence of Rabies Virus Exposure among Humans in the Peruvian Amazon

TLDR
Survey data suggest nonfatal exposure of persons to rabies virus, which is likely associated with vampire bat depredation.

Estimating the Global Burden of Endemic Canine Rabies

TLDR
Investment in dog vaccination, the single most effective way of reducing the disease burden, has been inadequate and that the availability and affordability of PEP needs improving, demonstrating that collaboration by medical and veterinary sectors could dramatically reduce the current large, and unnecessary, burden of rabies on affected communities.

Resolving the roles of immunity, pathogenesis, and immigration for rabies persistence in vampire bats

TLDR
Simulations show that the strong spatial component to transmission dynamics could explain the failure of bat culls to eliminate rabies and suggests that geographic coordination of control efforts might reduce transmission to humans and domestic animals.

Phylodynamics reveals extinction–recolonization dynamics underpin apparently endemic vampire bat rabies in Costa Rica

TLDR
The results highlight the importance of international viral dispersal for shaping the burden of rabies in Costa Rica, suggest a Central American corridor ofrabies virus invasions between continents, and show that apparent disease endemicity may arise through recurrent pathogen extinctions and reinvasions which can be readily detected in relatively small datasets by joining phylodynamic and modelling approaches.