Knowledge environments representing molecular entities for the virtual physiological human

  title={Knowledge environments representing molecular entities for the virtual physiological human},
  author={Martin Hofmann-Apitius and Juliane Fluck and Laura In{\'e}s Furlong and Oriol Fornes and Corinna Kol{\'a}rik and Susanne Hanser and Martin Boeker and Stefan Schulz and Ferran Sanz and Roman Klinger and Theo Mevissen and Tobias Gattermayer and Baldomero Oliva and C. Friedrich},
  journal={Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
  pages={3091 - 3110}
  • M. Hofmann-Apitius, J. Fluck, C. Friedrich
  • Published 13 September 2008
  • Biology, Computer Science
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
In essence, the virtual physiological human (VPH) is a multiscale representation of human physiology spanning from the molecular level via cellular processes and multicellular organization of tissues to complex organ function. The different scales of the VPH deal with different entities, relationships and processes, and in consequence the models used to describe and simulate biological functions vary significantly. Here, we describe methods and strategies to generate knowledge environments… 

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