Knowledge-based model of a glucosyltransferase from the oral bacterial group of mutans streptococci.

@article{Devulapalle1997KnowledgebasedMO,
  title={Knowledge-based model of a glucosyltransferase from the oral bacterial group of mutans streptococci.},
  author={Kumari S Devulapalle and Steven D Goodman and Q Gao and Anna Hemsley and Gregory Mooser},
  journal={Protein science : a publication of the Protein Society},
  year={1997},
  volume={6 12},
  pages={2489-93}
}
Mutans streptococci glucosyltransferases catalyze glucosyl transfer from sucrose to a glucan chain. We previously identified an aspartyl residue that participates in stabilizing the glucosyl transition state. The sequence surrounding the aspartate was found to have substantial sequence similarity with members of alpha-amylase family. Because little is known of the protein structure beyond the amino acid sequence, we used a knowledge-based interactive algorithm, MACAW, which provided significant… CONTINUE READING
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