Knowledge-Based Reconstruction of mRNA Transcripts with Short Sequencing Reads for Transcriptome Research

@inproceedings{Seok2012KnowledgeBasedRO,
  title={Knowledge-Based Reconstruction of mRNA Transcripts with Short Sequencing Reads for Transcriptome Research},
  author={Junhee Seok and Weihong Xu and Hui Jiang and Ronald W. Davis and Wenzhong Xiao},
  booktitle={PloS one},
  year={2012}
}
While most transcriptome analyses in high-throughput clinical studies focus on gene level expression, the existence of alternative isoforms of gene transcripts is a major source of the diversity in the biological functionalities of the human genome. It is, therefore, essential to annotate isoforms of gene transcripts for genome-wide transcriptome studies. Recently developed mRNA sequencing technology presents an unprecedented opportunity to discover new forms of transcripts, and at the same… CONTINUE READING
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