Knowing when to stop

  title={Knowing when to stop},
  author={Mick F. Tuite and Ian Stansfield},
Trade-off between reducing mutational accumulation and increasing commitment
Estimating the likelihood of cancer in the presence of mutations that enhance self-proliferation is demonstrated, demonstrating that a trade-off exists between mutation accumulation and the strength of washing out.
An Experimental Mathematics Perspective on the Old, and still Open, Question of When To Stop?
In a recent article in American Scientist, Theodore Hill described a coin-tossing game whose pay-off is the number of heads over the total number of throws. Suppose that at a given point during the
Broken Games and the Perpetual Update Culture: Revising Failure With Ubisoft’s Assassin’s Creed Unity
This article explores tensions between producers and audiences over the growing trend of broken games as developers rush error-ridden titles to market and update them after their release. Through the
UDO: Universal Database Optimization using Reinforcement Learning
This work evaluates UDO on Postgres as well as MySQL and on TPC-H as wellAs T PC-C, optimizing a variety of light and heavy parameters concurrently, to cater to different parameter types.
Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts
This review provides a suggested approach for the assessment and diagnosis of DTC in routine clinical practice, including the use of neck ultrasound, measurement of serum thyroid-stimulating hormone and calcitonin, fine-needle aspiration, cytology, and molecular imaging.
Trade-off between reducing mutational load and increasing commitment to differentiation determines tissue organization
Analytically estimating the likelihood of cancer, it is demonstrated that a trade-off exists between mutation accumulation and the strength of washing out, which explains the differences in the organization of widely different hierarchically differentiating tissues.
Applications of Optimal Stopping Algorithm for Social Graph Based Recommendation
A general recursive optimal stopping algorithm is proposed, providing an efficient way to search for best set of users to recommend movies from throughout the social network.
Association of the Cumulative Dose of Radioactive Iodine Therapy With Overall Survival in Patients With Differentiated Thyroid Cancer and Pulmonary Metastases
RAIT should be assigned to RAI-avid patients until disease has been controlled or RAIT becomes refractory after consideration of the potential long-term side-effects.
The Ultimatum Heuristic in Mixed-Motive Noncooperative Games
Mixed-motive noncooperative games feature ambivalence in the competitive relation of the players and outcomes disobliging Nash equilibrium prescription. The Nash approach, ostensibly rational and
From “Trivial Little Comedy” to “Legitimate Magic”: Music and the Making of The Glass Menagerie
The Glass Menagerie was Tennessee Williams’s first success, both commercial and critical, and remains one of the most frequently revived of all American plays.1 For its original production, Williams


A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor
The assignment of a family of tightly related proteins from lower and higher eukaryotes which are structurally and functionally similar to rabbit eRF are reported, concluding that the eRFl proteins are directly implicated in the termination of translation in eukARYotes.
Psi no more for yeast prions
[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.
The genetic evidence presented here suggests that protein-based inheritance, involving a protein unrelated to the mammalian prion protein, can occur in a microorganism.
In Xenopus laevis, the product of a developmentally regulated mRNA is structurally and functionally homologous to a Saccharomyces cerevisiae protein involved in translation fidelity.
Xenopus Cl1 cDNA was able to suppress sup45-related phenotypes, showing that the structural homology reflects a functional homology, and implies that the function of SUP45 is not restricted to lower eukaryotes and that the SUP45 protein may perform a crucial cellular function in higher eUKaryotes.
Mammalian polypeptide chain release factor and tryptophanyl‐tRNA synthetase are distinct proteins.
It is shown that functionally distinct WRS and eRF proteins can be completely separated from each other, and a putative anti‐eRF monoclonal antibody appears incapable of immunoprecipitating the e RF activity or binding to protein(s) possessing eRF activity.
Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.
The cloning of a mammalian RF cDNA is reported by the use of monoclonal antibodies specific for rabbit RF, and it is shown that, when expressed in Escherichia coli, the protein encoded by this cDNA has in vitro biochemical characteristics similar to those of previously characterized mammalian RFs.
Allosuppressors in yeast
It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons and that the [ psi + ] factor or its product affects protein synthesis by interaction with the ribosome.
Characterization of reticulocyte release factor.
Peptide chain termination. 3. Stimulation of in vitro termination.
Purification of the components of the release assay has enabled identification of a protein factor S in the 55-80 per cent ammonium sulfate fraction of E. coli B supernatant fraction, but further purification is required to determine the nature and function of S in peptide chain termination.