Knowing when to let go


uring meiosis I, some mechanism must allow homologous chromosomes to separate while keeping sister chromatids paired until meiosis II. How does a cell make this distinction? On page 219, Rogers et al. propose that in C. elegans the aurora-B kinase AIR-2 is largely responsible for ensuring that cohesion between chromosomes breaks down at the proper place and time. The authors also identified additional components in what is likely to be a conserved pathway controlling chromosome cohesion. When AIR-2 activity is inhibited by RNAi, meiotic cells in the worm do not D

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@article{Dove2002KnowingWT, title={Knowing when to let go}, author={Alan W. Dove}, journal={The Journal of Cell Biology}, year={2002}, volume={157}, pages={195 - 195} }