Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus.

@article{Kohlmeier2012KnockoutsRO,
  title={Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus.},
  author={Kristi A Kohlmeier and Masaru Ishibashi and Juergen Wess and Martha E Bickford and Christopher S Leonard},
  journal={Journal of neurophysiology},
  year={2012},
  volume={108 10},
  pages={2751-66}
}
Cholinergic neurons in the laterodorsal tegmental (LDT) and peduncolopontine tegmental (PPT) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. Muscarinic acetylcholine receptors (mAChRs) on LDT neurons produce a membrane hyperpolarization and inhibit spike-evoked Ca(2… CONTINUE READING