Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.

@article{Copeland2013KnockoutOT,
  title={Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.},
  author={Ben T. Copeland and Matthew J. Bowman and Claude Boucheix and Leonie K. Ashman},
  journal={International journal of cancer},
  year={2013},
  volume={133 8},
  pages={1803-12}
}
Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also prove to be therapeutic antimetastatic targets. The tetraspanin group of molecules are integral membrane proteins that associate with motility-related proteins such as integrins… CONTINUE READING

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