Knockout of the regulatory factor X1 gene leads to early embryonic lethality.

@article{Feng2009KnockoutOT,
  title={Knockout of the regulatory factor X1 gene leads to early embryonic lethality.},
  author={Chenzhuo Feng and Wenhao Xu and Zhiyi Zuo},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={386 4},
  pages={715-7}
}
The biological function of regulatory factor X1 (RFX1), the prototype member of the transcription factor RFX family, is not clear. We have used gene trap technique to disrupt the expression of RFX1 in mice. Although, heterozygous RFX1(+/-) mice appear normal and fertile, homozygous RFX1(-/-) embryos died at an early stage (most likely before embryonic day 2… CONTINUE READING