Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons.

@article{Harburg2007KnockoutOT,
  title={Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons.},
  author={Gwyndolen C. Harburg and F. Scott Hall and Alexia V Harrist and Ichiro Sora and George R. Uhl and Amelia J Eisch},
  journal={Neuroscience},
  year={2007},
  volume={144 1},
  pages={77-87}
}
Recent evidence suggests that mu opioid receptors (MOR) are key regulators of hippocampal structure and function. For example, exogenous MOR agonists morphine and heroin negatively impact hippocampal function and decrease adult hippocampal neurogenesis. Here we explored the role of MOR in the birth and survival of hippocampal progenitor cells by examining adult neurogenesis in mice that lack MOR. Adult male mice lacking exon 1 of MOR were injected with the S phase marker bromodeoxyuridine (BrdU… CONTINUE READING

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