Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans

@inproceedings{Austin2010KnockoutOT,
  title={Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans},
  author={Misa U Austin and Wei-Siang Liau and Krishnaswamy Balamurugan and Balasubramaniem Ashokkumar and Hamid M Said and Craig W Lamunyon},
  booktitle={BMC Developmental Biology},
  year={2010}
}
BackgroundThe C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the source of the sterility and the effect of the folt-1 knockout on somatic function.ResultsOur results show that folt-1(ok1460) knockout hermaphrodites have a substantially reduced… CONTINUE READING

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