Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine

@article{Wang1997KnockoutOT,
  title={Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine},
  author={Yan-min Wang and Raul R Gainetdinov and Fabio Fumagalli and Fei Xu and Sara R Jones and Cheryl B. Bock and Gary W. Miller and R H Wightman and Marc G. Caron},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={1285-1296}
}
Vesicular monoamine transporters are known to transport monoamines from the cytoplasm into secretory vesicles. We have used homologous recombination to generate mutant mice lacking the vesicular monoamine transporter 2 (VMAT2), the predominant form expressed in the brain. Newborn homozygotes die within a few days after birth, manifesting severely impaired… CONTINUE READING