Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.


Homo sapiens longevity assurance homolog 2 of yeast LAG (Lass2) catalyzes the synthesis of long-chain ceramide which is an essential element of membranous structures. Deletion of Lass2 is associated with a high risk of spontaneous or DEN-induced hepatocellular carcinoma (HCC), yet the mechanism remains unclear. In the present study, we found extensive… (More)
DOI: 10.3892/or.2014.3527


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