Knockout of miR-221 and miR-222 reveals common and specific targets for paralogous miRNAs.

@article{Jeong2017KnockoutOM,
  title={Knockout of miR-221 and miR-222 reveals common and specific targets for paralogous miRNAs.},
  author={Geon Jeong and Yeong-Hwan Lim and Nam Joong Kim and Gabbine Wee and Young Kook Kim},
  journal={RNA biology},
  year={2017},
  volume={14 2},
  pages={197-205}
}
MicroRNAs (miRNAs) regulate the expression of mRNA through sequence-specific binding of the 3' untranslated region (UTR). The seed sequence of miRNAs is the key determinant for target site recognition. Paralogous miRNAs, which share the same seed sequences but differ in their 3' regions, are known to regulate largely overlapping groups of mRNAs. However, no… CONTINUE READING