Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress.

@article{Fu1999KnockoutOC,
  title={Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress.},
  author={Yu-qiang Fu and William Cheng and Jesus M Porres and David Anthony D. Ross and Xingen G. Lei},
  journal={Free radical biology & medicine},
  year={1999},
  volume={27 5-6},
  pages={
          605-11
        }
}
Two experiments were conducted to determine the protection and the underlying mechanisms of cellular glutathione peroxidase (GPX1) against lethal, acute oxidative stress induced by an intraperitoneal injection of 24 mg diquat/kg body weight. In experiment 1, mortality and survival times were compared among selenium (Se)-adequate or deficient GPX1 knockout mice [GPX1(-/-)] and wild-type mice (WT). In experiment 2, mice from these four groups were euthanized at 0, 1, 2, and 3 h after the… CONTINUE READING

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