Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa.

  title={Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa.},
  author={Congrong Guo and Atsushi Otani and Akio Oishi and Hiroshi Kojima and Yukiko Makiyama and Satoko Nakagawa and Nagahisa Yoshimura},
  journal={Experimental eye research},
Neuroinflammation involving CC chemokines such as monocyte chemoattractant protein-1 (MCP-1) has been demonstrated in the pathological process of retinitis pigmentosa (RP), an inherited degenerative retinal disease. However, the mechanism of MCP-1 and its receptor CCR2 involvement in the disease remains unclear. To investigate the role of MCP1/CCR2 in RP pathogenesis, ccr2 mutant RP mice (ccr2(-/-) rd10) were created and analyzed. The expression of MCP-1, RANTES, stromal cell-derived factor… CONTINUE READING
18 Citations
31 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 31 references

hematopoietic stem/progenitor cells in muscles. Stem Cells

  • K. Saijo, C. K. Glass
  • Nat. Rev. Immunol
  • 2011
1 Excerpt

macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice

  • B. D. Semple, N. Bye, M. Rancan, J. M. Ziebell, M. C. Morganti-Kossmann
  • Exp Neurol
  • 2010
2 Excerpts

Similar Papers

Loading similar papers…