Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa.

@article{Guo2012KnockoutOC,
  title={Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa.},
  author={Congrong Guo and Atsushi Otani and Akio Oishi and Hiroshi Kojima and Yukiko Makiyama and Satoko Nakagawa and Nagahisa Yoshimura},
  journal={Experimental eye research},
  year={2012},
  volume={104},
  pages={39-47}
}
Neuroinflammation involving CC chemokines such as monocyte chemoattractant protein-1 (MCP-1) has been demonstrated in the pathological process of retinitis pigmentosa (RP), an inherited degenerative retinal disease. However, the mechanism of MCP-1 and its receptor CCR2 involvement in the disease remains unclear. To investigate the role of MCP1/CCR2 in RP pathogenesis, ccr2 mutant RP mice (ccr2(-/-) rd10) were created and analyzed. The expression of MCP-1, RANTES, stromal cell-derived factor… CONTINUE READING
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