Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice

@article{Glaser2007KnockoutO,
  title={Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice},
  author={Shannon S. Glaser and Yoshiyuki Ueno and Sharon DeMorrow and Valorie L. Chiasson and Khurshed A. Katki and Julie K Venter and Heather Francis and Ian M. Dickerson and Donald J Dipette and Scott C. Supowit and Gianfranco D Alpini},
  journal={Laboratory Investigation},
  year={2007},
  volume={87},
  pages={914-926}
}
The role of sensory innervation in the regulation of liver physiology and the pathogenesis of cholestatic liver disease are undefined. Biliary proliferation has been shown to be coordinately controlled by parasympathetic and sympathetic innervation of the liver. The aim of our study was to address the role of the sensory neuropeptide calcitonin gene-related peptide (α-CGRP) in the regulation of cholangiocyte proliferation during cholestasis induced by extrahepatic bile duct obstruction (BDL… CONTINUE READING

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Substance P stimulates biliary growth during cholestasis induced by extrahepatic bile duct obstruction ( BDL ) via activation of ERK 1 / 2 / p 38 / CREB signaling mechanisms

  • S Glaser, K Katki, S DeMorrow
  • Hepatology
  • 2006

Substance P stimulates biliary growth during cholestasis induced by extrahepatic bile duct obstruction (BDL) via activation of ERK1/2/p38/CREB signaling mechanisms. Hepatology 2006;44:602A

  • S Glaser, K Katki, S DeMorrow
  • 2006
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