Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors.

@article{Reuter2002KnockoutMF,
  title={Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors.},
  author={Hannes Reuter and Scott A. Henderson and Tieyan Han and Toshio Matsuda and A. Ramesha Baba and Robert S Ross and Joshua I. Goldhaber and Kenneth D. Philipson},
  journal={Circulation research},
  year={2002},
  volume={91 2},
  pages={90-2}
}
The role of the Na+-Ca2+ exchanger as a major determinant of cell Ca2+ is well defined in cardiac tissue, and there has been much effort to develop specific inhibitors of the exchanger. We use a novel system to test the specificity of two putative specific inhibitors, KB-R7943 and SEA0400. The drugs are applied to electrically stimulated heart tubes from control mouse embryos or embryos with the Na+-Ca2+ exchanger knocked out. We monitored effects of the drugs on Ca2+ transients. Both drugs… CONTINUE READING

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