Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling.

@article{Davies2008KnockdownRT,
  title={Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling.},
  author={T. G. Emyr Davies and Andrias O O'Reilly and Linda M. Field and B. A. Wallace and Martin S. Williamson},
  journal={Pest management science},
  year={2008},
  volume={64 11},
  pages={1126-30}
}
Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes. The correct functioning of these channels is essential for the normal transmission of nerve impulses, and this process is disrupted by binding of the insecticides, leading to paralysis and eventual death. Some insect pest populations have evolved modifications of the sodium channel protein that… CONTINUE READING

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