Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells.

@article{Wei2013KnockdownOT,
  title={Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells.},
  author={Jinying Wei and Yonghong Shi and Yanjuan Hou and Yunzhuo Ren and Chunyang Du and Lianshan Zhang and Ying Li and Huijun Duan},
  journal={Cellular signalling},
  year={2013},
  volume={25 12},
  pages={
          2788-96
        }
}
Epithelial to mesenchymal transition (EMT) of tubular cells contributes to the renal accumulation of matrix protein that is associated with diabetic nephropathy. Both high glucose and transforming growth factor-β (TGF-β) are able to induce EMT in cell culture. In this study, we examined the role of the thioredoxin-interacting protein (TXNIP) on EMT induced by high glucose or TGF-β1 in HK-2 cells. EMT was assessed by the expression of α-smooth muscle actin (α-SMA) and E-cadherin and the… CONTINUE READING
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