Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma.

@article{Jung2010KnockdownOT,
  title={Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma.},
  author={Il Lae Jung and Hyo Jin Kang and Kug Chan Kim and In-Gyu Kim},
  journal={International journal of molecular medicine},
  year={2010},
  volume={26 1},
  pages={33-8}
}
The expression of the Wnt-antagonist Dickkopf gene (DKK) is downregulated in several types of tumors as a consequence of epigenetic DNA modification; four DKK members, DKK1, DKK2, DKK3, and DKK4, have been identified. In this study, we investigated another function of DKK3 in non-small cell lung cancer H460 cells, in which DKK3 was hypermethylated (44%) but still expressed, by interfering with DKK3 expression using DKK3-silencing RNA (SiRNA). We found that knockdown of DKK3 expression by DKK3… CONTINUE READING
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