Knockdown of spinal cord postsynaptic density protein-95 prevents the development of morphine tolerance in rats.

@article{Liaw2004KnockdownOS,
  title={Knockdown of spinal cord postsynaptic density protein-95 prevents the development of morphine tolerance in rats.},
  author={W-J Liaw and Bo Zhang and Feng Tao and Myron Yaster and Roger A. Johns and Ya-Xiong Tao},
  journal={Neuroscience},
  year={2004},
  volume={123 1},
  pages={11-5}
}
The activation of spinal cord N-methyl-D-aspartate (NMDA) receptors and subsequent intracellular cascades play a pivotal role in the development of opioid tolerance. Postsynaptic density protein-95 (PSD-95), a molecular scaffolding protein, assembles a specific set of signaling proteins around NMDA receptors at neuronal synapses. The current study investigated the possible involvement of PSD-95 in the development of opioid tolerance. Opioid tolerance was induced by intrathecal injection of… CONTINUE READING

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